Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

Autophagy is an essential cellular degradation pathway in neurons; defects in autophagy are sufficient to induce neurodegeneration. In this paper, we investigate autophagosome dynamics in primary dorsal root ganglion neurons. Autophagosome biogenesis occurs distally in a constitutive process at the...

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Detalles Bibliográficos
Autores principales: Maday, Sandra, Wallace, Karen E., Holzbaur, Erika L.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283992/
https://www.ncbi.nlm.nih.gov/pubmed/22331844
http://dx.doi.org/10.1083/jcb.201106120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283992/
https://www.ncbi.nlm.nih.gov/pubmed/22331844
http://dx.doi.org/10.1083/jcb.201106120

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