Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes

BACKGROUND: Atypical expression of cell cycle regulatory proteins has been implicated in Alzheimer's disease (AD), but the molecular mechanisms by which they induce neurodegeneration are not well understood. We examined transgenic mice expressing human amyloid precursor protein (APP) and presen...

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Detalles Bibliográficos
Autores principales: Judge, Monique, Hornbeck, Lisa, Potter, Huntington, Padmanabhan, Jaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284477/
https://www.ncbi.nlm.nih.gov/pubmed/22112898
http://dx.doi.org/10.1186/1750-1326-6-80

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284477/
https://www.ncbi.nlm.nih.gov/pubmed/22112898
http://dx.doi.org/10.1186/1750-1326-6-80

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