Neurodegeneration and Motor Dysfunction in Mice Lacking Cytosolic and Mitochondrial Aldehyde Dehydrogenases: Implications for Parkinson's Disease

Previous studies have reported elevated levels of biogenic aldehydes in the brains of patients with Parkinson's disease (PD). In the brain, aldehydes are primarily detoxified by aldehyde dehydrogenases (ALDH). Reduced ALDH1 expression in surviving midbrain dopamine neurons has been reported in...

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Detalles Bibliográficos
Autores principales: Wey, Margaret Chia-Ying, Fernandez, Elizabeth, Martinez, Paul Anthony, Sullivan, Patricia, Goldstein, David S., Strong, Randy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284575/
https://www.ncbi.nlm.nih.gov/pubmed/22384032
http://dx.doi.org/10.1371/journal.pone.0031522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284575/
https://www.ncbi.nlm.nih.gov/pubmed/22384032
http://dx.doi.org/10.1371/journal.pone.0031522

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