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Selection of Monoclonal Antibodies Against 6-oxo-M(1)dG and Their Use in an LC-MS/MS Assay for the Presence of 6-oxo-M(1)dG in Vivo
[Image: see text] Oxidative stress triggers DNA and lipid peroxidation, leading to the formation of electrophiles that react with DNA to form adducts. A product of this pathway, (3-(2′-deoxy-β-d-erythro-pentofuranosyl)-pyrimido[1,2-α]purine-10(3H)-one), or M(1)dG, is mutagenic in bacterial and mamma...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285145/ https://www.ncbi.nlm.nih.gov/pubmed/22211372 http://dx.doi.org/10.1021/tx200494h |