Systematic Evaluation of the Metabolic to Mitogenic Potency Ratio for B10-Substituted Insulin Analogues

BACKGROUND: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have been subject to much scrutiny and debate. However, B10 is still an attra...

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Detalles Bibliográficos
Autores principales: Glendorf, Tine, Knudsen, Louise, Stidsen, Carsten E., Hansen, Bo F., Hegelund, Anne Charlotte, Sørensen, Anders R., Nishimura, Erica, Kjeldsen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285154/
https://www.ncbi.nlm.nih.gov/pubmed/22383948
http://dx.doi.org/10.1371/journal.pone.0029198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285154/
https://www.ncbi.nlm.nih.gov/pubmed/22383948
http://dx.doi.org/10.1371/journal.pone.0029198

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