Carbinolamine Formation and Dehydration in a DNA Repair Enzyme Active Site

In order to suggest detailed mechanistic hypotheses for the formation and dehydration of a key carbinolamine intermediate in the T4 pyrimidine dimer glycosylase (T4PDG) reaction, we have investigated these reactions using steered molecular dynamics with a coupled quantum mechanics–molecular mechanic...

Descripción completa

Detalles Bibliográficos
Autores principales: Dodson, M. L., Walker, Ross C., Lloyd, R. Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285167/
https://www.ncbi.nlm.nih.gov/pubmed/22384015
http://dx.doi.org/10.1371/journal.pone.0031377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285167/
https://www.ncbi.nlm.nih.gov/pubmed/22384015
http://dx.doi.org/10.1371/journal.pone.0031377

Ejemplares similares