Cargando…

Thioredoxin Glutathione Reductase as a Novel Drug Target: Evidence from Schistosoma japonicum

BACKGROUND: Schistosomiasis remains a major public health concern affecting billions of people around the world. Currently, praziquantel is the only drug of choice for treatment of human schistosomiasis. The emergence of drug resistance to praziquantel in schistosomes makes the development of novel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, LiJun, Li, JiaHuang, Xie, ShuYing, Qian, ChunYan, Wang, Jie, Zhang, Wei, Yin, XuRen, Hua, ZiChun, Yu, ChuanXin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285170/ https://www.ncbi.nlm.nih.gov/pubmed/22384025 http://dx.doi.org/10.1371/journal.pone.0031456

Ejemplares similares

Identification of Peptide Antagonists to Thioredoxin Glutathione Reductase of Schistosoma japonicum
por: Song, Li-Jun, et al.
Publicado: (2018)

Molecular docking to explore the possible binding mode of potential inhibitors of thioredoxin glutathione reductase
por: HUANG, JINGWEI, et al.
Publicado: (2015)

Cheminformatics Models for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase
por: Gaba, Sonam, et al.
Publicado: (2014)

Gene Gun Bombardment with DNA-Coated Golden Particles Enhanced the Protective Effect of a DNA Vaccine Based on Thioredoxin Glutathione Reductase of Schistosoma japonicum
por: Cao, Yan, et al.
Publicado: (2013)

Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target
por: Kuntz, Angela N, et al.
Publicado: (2007)

Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target
por: Kuntz, Angela N, et al.
Publicado: (2007)

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase
por: Prigge, Justin R., et al.
Publicado: (2017)

Blocking BAFF Alleviates Hepatic Fibrosis in Schistosoma japonicum-Infected Mice
por: Dong, Panpan, et al.
Publicado: (2023)

Characterizing Roles for the Glutathione Reductase, Thioredoxin Reductase and Thioredoxin Peroxidase-Encoding Genes of Magnaporthe oryzae during Rice Blast Disease
por: Fernandez, Jessie, et al.
Publicado: (2014)

Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo
por: Petukhova, Valentina Z., et al.
Publicado: (2023)

Identification of Thioredoxin Glutathione Reductase Inhibitors That Kill Cestode and Trematode Parasites
por: Ross, Fabiana, et al.
Publicado: (2012)

Mitochondrial Thioredoxin-Glutathione Reductase from Larval Taenia crassiceps (Cysticerci)
por: Guevara-Flores, Alberto, et al.
Publicado: (2010)

Structural Analysis of Glutaredoxin Domain of Mus musculus Thioredoxin Glutathione Reductase
por: Dobrovolska, Olena, et al.
Publicado: (2012)

Detection of canine Schistosoma japonicum infection using recombinant thioredoxin peroxidase-1 and tandem repeat proteins
por: ANGELES, Jose Ma. M., et al.
Publicado: (2019)

Evaluation of Schistosoma japonicum thioredoxin peroxidase-1 as a potential circulating antigen target for the diagnosis of Asian schistosomiasis
por: MACALANDA, Adrian Miki C., et al.
Publicado: (2017)

Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function
por: Ke, Xue-Dan, et al.
Publicado: (2017)

Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia
por: Wall, Stephanie B., et al.
Publicado: (2019)

Assigning function to active site residues of Schistosoma mansoni thioredoxin/glutathione reductase from analysis of transient state reductive half-reactions with variant forms of the enzyme
por: Smith, Madison M., et al.
Publicado: (2023)

Detection of the circulating antigen 14-3-3 protein of Schistosoma japonicum by time-resolved fluoroimmunoassay in rabbits
por: Qian, Chun-Yan, et al.
Publicado: (2011)

Insight into the Mechanistic Basis of the Hysteretic-Like Kinetic Behavior of Thioredoxin-Glutathione Reductase (TGR)
por: Rendón, Juan L., et al.
Publicado: (2018)

Deficiency of PKCλ/ι alleviates the liver pathologic impairment of Schistosoma japonicum infection by thwarting Th2 response
por: Mei, Congjin, et al.
Publicado: (2022)

Thioredoxin reductase: A novel, independent prognostic marker in patients with hepatocellular carcinoma
por: Li, Chunyan, et al.
Publicado: (2015)

A Cytochrome b561 with Ferric Reductase Activity from the Parasitic Blood Fluke, Schistosoma japonicum
por: Glanfield, Amber, et al.
Publicado: (2010)

Utilization of ELISA Using Thioredoxin Peroxidase-1 and Tandem Repeat Proteins for Diagnosis of Schistosoma japonicum Infection among Water Buffaloes
por: Angeles, Jose Ma. M., et al.
Publicado: (2012)

A strategy for emergency treatment of Schistosoma japonicum-infested water
por: Liang, You-Sheng, et al.
Publicado: (2011)

Schistosoma japonicum Cystatin Alleviates Sepsis Through Activating Regulatory Macrophages
por: Xie, Hong, et al.
Publicado: (2021)

Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum
por: Wang, Wen-Long, et al.
Publicado: (2013)

Functional characterisation of Schistosoma japonicum acetylcholinesterase
por: You, Hong, et al.
Publicado: (2016)

Jejunal Ulcer Caused by Schistosoma japonicum
por: Rivadeneira, Daniela Jaqueline, et al.
Publicado: (2019)

Schistosoma japonicum Associated With Colorectal Cancer
por: Almoghrabi, Anas, et al.
Publicado: (2021)

Exploring molecular variation in Schistosoma japonicum in China
por: Young, Neil D., et al.
Publicado: (2015)

Nested-PCR assay for detection of Schistosoma japonicum infection in domestic animals
por: Zhang, Xin, et al.
Publicado: (2017)

An improved genome assembly of the fluke Schistosoma japonicum
por: Luo, Fang, et al.
Publicado: (2019)

Aldose reductase from Schistosoma japonicum: crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds
por: Liu, Jian, et al.
Publicado: (2013)

Thioredoxin Reductase and its Inhibitors
por: Saccoccia, Fulvio, et al.
Publicado: (2014)

First Evidence of Function for Schistosoma japonicum riok-1 and RIOK-1
por: Mughal, Mudassar N., et al.
Publicado: (2021)

An association of Aquaporin-4 with the immunoregulation of liver pathology in mice infected with Schistosoma japonicum
por: Zhang, Weiwei, et al.
Publicado: (2015)

High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis
por: Li, Ting, et al.
Publicado: (2015)

Molecular and functional characterization of Schistosoma japonicum annexin A13
por: Zhong, Haoran, et al.
Publicado: (2023)

Transmission Dynamics of Schistosoma japonicum in the Lakes and Marshlands of China
por: Gray, Darren J., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_sc18qst6d1k6f8nihchia1e0ek