A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity

Huntington's disease (HD) is an autosomal dominantly inherited disorder caused by the expansion of CAG repeats in the Huntingtin (HTT) gene. The abnormally extended polyglutamine in the HTT protein encoded by the CAG repeats has toxic effects. Here, we provide evidence to support that the mutan...

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Detalles Bibliográficos
Autores principales: Bañez-Coronel, Mónica, Porta, Silvia, Kagerbauer, Birgit, Mateu-Huertas, Elisabet, Pantano, Lorena, Ferrer, Isidre, Guzmán, Manuel, Estivill, Xavier, Martí, Eulàlia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285580/
https://www.ncbi.nlm.nih.gov/pubmed/22383888
http://dx.doi.org/10.1371/journal.pgen.1002481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285580/
https://www.ncbi.nlm.nih.gov/pubmed/22383888
http://dx.doi.org/10.1371/journal.pgen.1002481

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