The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold

Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are characterized by early suppression of the host innate immune system. One of the proteins likely responsible for this effect is VP24. VP24 is known to antagonize interferon signaling by binding host karyopherin α pr...

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Detalles Bibliográficos
Autores principales: Zhang, Adrianna P. P., Bornholdt, Zachary A., Liu, Tong, Abelson, Dafna M., Lee, David E., Li, Sheng, Woods, Virgil L., Saphire, Erica Ollmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285596/
https://www.ncbi.nlm.nih.gov/pubmed/22383882
http://dx.doi.org/10.1371/journal.ppat.1002550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285596/
https://www.ncbi.nlm.nih.gov/pubmed/22383882
http://dx.doi.org/10.1371/journal.ppat.1002550

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