Transient Reversal of Episome Silencing Precedes VP16-Dependent Transcription during Reactivation of Latent HSV-1 in Neurons

Herpes simplex virus type-1 (HSV-1) establishes latency in peripheral neurons, creating a permanent source of recurrent infections. The latent genome is assembled into chromatin and lytic cycle genes are silenced. Processes that orchestrate reentry into productive replication (reactivation) remain p...

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Detalles Bibliográficos
Autores principales: Kim, Ju Youn, Mandarino, Angelo, Chao, Moses V., Mohr, Ian, Wilson, Angus C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285597/
https://www.ncbi.nlm.nih.gov/pubmed/22383875
http://dx.doi.org/10.1371/journal.ppat.1002540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285597/
https://www.ncbi.nlm.nih.gov/pubmed/22383875
http://dx.doi.org/10.1371/journal.ppat.1002540

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