FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization

Genetic studies revealed that the ablation of insulin/IGF-1 signaling in the pancreas causes diabetes. FoxO1 is a downstream transcription factor of insulin/IGF-1 signaling. We previously reported that FoxO1 haploinsufficiency restored β cell mass and rescued diabetes in IRS2 knockout mice. However,...

Descripción completa

Detalles Bibliográficos
Autores principales: Kikuchi, Osamu, Kobayashi, Masaki, Amano, Kosuke, Sasaki, Tsutomu, Kitazumi, Tomoya, Kim, Hye-Jin, Lee, Yong-Soo, Yokota-Hashimoto, Hiromi, Kitamura, Yukari-Ido, Kitamura, Tadahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285669/
https://www.ncbi.nlm.nih.gov/pubmed/22384192
http://dx.doi.org/10.1371/journal.pone.0032249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285669/
https://www.ncbi.nlm.nih.gov/pubmed/22384192
http://dx.doi.org/10.1371/journal.pone.0032249

Ejemplares similares