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FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization
Genetic studies revealed that the ablation of insulin/IGF-1 signaling in the pancreas causes diabetes. FoxO1 is a downstream transcription factor of insulin/IGF-1 signaling. We previously reported that FoxO1 haploinsufficiency restored β cell mass and rescued diabetes in IRS2 knockout mice. However,...
Autores principales: | Kikuchi, Osamu, Kobayashi, Masaki, Amano, Kosuke, Sasaki, Tsutomu, Kitazumi, Tomoya, Kim, Hye-Jin, Lee, Yong-Soo, Yokota-Hashimoto, Hiromi, Kitamura, Yukari-Ido, Kitamura, Tadahiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285669/ https://www.ncbi.nlm.nih.gov/pubmed/22384192 http://dx.doi.org/10.1371/journal.pone.0032249 |
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