Active Site Mutations Change the Cleavage Specificity of Neprilysin

Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides. We have generated a series of neprilysin variants containing mutations at either one of two active site residues, Phe(563)...

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Detalles Bibliográficos
Autores principales: Sexton, Travis, Hitchcook, Lisa J., Rodgers, David W., Bradley, Luke H., Hersh, Louis B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285688/
https://www.ncbi.nlm.nih.gov/pubmed/22384224
http://dx.doi.org/10.1371/journal.pone.0032343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285688/
https://www.ncbi.nlm.nih.gov/pubmed/22384224
http://dx.doi.org/10.1371/journal.pone.0032343

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