The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation

Cyclin-dependent kinase 5 (Cdk5) has been identified as a determinant of sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. Here, the consequences of its depletion on cell survival, PARP activity, the recruitment of base excision repair (BER) proteins to DNA damage sites, and overall DNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Bolin, Celeste, Boudra, Mohammed-Tayyib, Fernet, Marie, Vaslin, Laurence, Pennaneach, Vincent, Zaremba, Tomasz, Biard, Denis, Cordelières, Fabrice P., Favaudon, Vincent, Mégnin-Chanet, Frédérique, Hall, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285760/
https://www.ncbi.nlm.nih.gov/pubmed/21922195
http://dx.doi.org/10.1007/s00018-011-0811-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285760/
https://www.ncbi.nlm.nih.gov/pubmed/21922195
http://dx.doi.org/10.1007/s00018-011-0811-6

Ejemplares similares