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Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import

BACKGROUND: Integration of human immunodeficiency virus type 1 (HIV-1) into a host cell chromosome is an essential step under the control of the viral integrase (IN). Although this enzyme is necessary and sufficient to catalyze the integration reaction in vitro, cellular cofactors are involved in th...

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Detalles Bibliográficos
Autores principales: Cribier, Alexandra, Ségéral, Emmanuel, Delelis, Olivier, Parissi, Vincent, Simon, Aurélie, Ruff, Marc, Benarous, Richard, Emiliani, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286403/
https://www.ncbi.nlm.nih.gov/pubmed/22176773
http://dx.doi.org/10.1186/1742-4690-8-104