Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes

Epigenetic gene silencing is an important mechanism in the initiation and progression of cancer. Abnormal DNA CpG island hypermethylation and histone modifications are involved in aberrant silencing of tumour-suppressor genes. LSD1 (lysine-specific demethylase 1) was the first enzyme identified to s...

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Detalles Bibliográficos
Autores principales: Wu, Yu, Steinbergs, Nora, Murray-Stewart, Tracy, Marton, Laurence J., Casero, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286856/
https://www.ncbi.nlm.nih.gov/pubmed/22132744
http://dx.doi.org/10.1042/BJ20111271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286856/
https://www.ncbi.nlm.nih.gov/pubmed/22132744
http://dx.doi.org/10.1042/BJ20111271

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