Cargando…

Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes

Epigenetic gene silencing is an important mechanism in the initiation and progression of cancer. Abnormal DNA CpG island hypermethylation and histone modifications are involved in aberrant silencing of tumour-suppressor genes. LSD1 (lysine-specific demethylase 1) was the first enzyme identified to s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Yu, Steinbergs, Nora, Murray-Stewart, Tracy, Marton, Laurence J., Casero, Robert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286856/ https://www.ncbi.nlm.nih.gov/pubmed/22132744 http://dx.doi.org/10.1042/BJ20111271

Ejemplares similares

Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder–Robinson syndrome
por: Stewart, Tracy Murray, et al.
Publicado: (2023)

Difluoromethylornithine (DFMO) and Neuroblastoma: A Review
por: Tangella, Adarsh Vardhan, et al.
Publicado: (2023)

Difluoromethylornithine Is a Novel Inhibitor of Helicobacter pylori Growth, CagA Translocation, and Interleukin-8 Induction
por: Barry, Daniel P., et al.
Publicado: (2011)

Therapy of murine squamous cell carcinomas with 2-difluoromethylornithine
por: Chen, Yan, et al.
Publicado: (2004)

Clinical importance of eflornithine (α-difluoromethylornithine) for the treatment of malignant gliomas
por: Levin, Victor A, et al.
Publicado: (2018)

Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci
por: Ayoola, Moses B., et al.
Publicado: (2022)

Thymoquinone and Difluoromethylornithine (DFMO) Synergistically Induce Apoptosis of Human Acute T Lymphoblastic Leukemia Jurkat Cells Through the Modulation of Epigenetic Pathways
por: Alhosin, Mahmoud, et al.
Publicado: (2020)

Metastasis of hormone-independent breast cancer to lung and bone is decreased by α-difluoromethylornithine treatment
por: Richert, Monica M, et al.
Publicado: (2005)

α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation
por: Hyvönen, Mervi T., et al.
Publicado: (2021)

Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells
por: El Naggar, Olivia, et al.
Publicado: (2022)

Expanded Potential of the Polyamine Analogue SBP-101 (Diethyl Dihydroxyhomospermine) as a Modulator of Polyamine Metabolism and Cancer Therapeutic
por: Holbert, Cassandra E., et al.
Publicado: (2022)

Snail silences suppressor
por: Maxmen, Amy
Publicado: (2009)

The Polyamine Inhibitor Alpha-Difluoromethylornithine Modulates Hippocampus-Dependent Function after Single and Combined Injuries
por: Rosi, Susanna, et al.
Publicado: (2012)

Effect of an Inhibitor of Tumor Promotion, α‐Difluoromethylornithine, on Tumor Induction by Repeated Beta Irradiation in Mice
por: Ootsuyama, Akira, et al.
Publicado: (1993)

The First Insight Into the Supramolecular System of D,L-α-Difluoromethylornithine: A New Antiviral Perspective
por: Bojarska, Joanna, et al.
Publicado: (2021)

Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours
por: Murai, M, et al.
Publicado: (2005)

Potentiating NK cell activity by combination of Rosuvastatin and Difluoromethylornithine for effective chemopreventive efficacy against Colon Cancer
por: Janakiram, Naveena B., et al.
Publicado: (2016)

Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases
por: LoGiudice, Nicole, et al.
Publicado: (2018)

Difluoromethylornithine attenuates isoproterenol-induced cardiac hypertrophy by regulating apoptosis, autophagy and the mitochondria-associated membranes pathway
por: Zhao, Yu, et al.
Publicado: (2021)

Viral Suppressors of Gene Silencing
por: Verchot-Lubicz, J., et al.
Publicado: (2008)

Aberrant Methylation Status of Tumour Suppressor Genes in Ovarian Cancer Tissue and Paired Plasma Samples
por: Dvorská, Dana, et al.
Publicado: (2019)

The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer
por: Kodach, Liudmila L., et al.
Publicado: (2010)

Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy
por: Holbert, Cassandra E., et al.
Publicado: (2022)

Role of obesity in a randomized placebo-controlled trial of difluoromethylornithine (DFMO) + sulindac for the prevention of sporadic colorectal adenomas
por: Zell, Jason A., et al.
Publicado: (2012)

Inhibiting Cycloxygenase and Ornithine Decarboxylase by Diclofenac and Alpha-Difluoromethylornithine Blocks Cutaneous SCCs by Targeting Akt-ERK Axis
por: Arumugam, Aadithya, et al.
Publicado: (2013)

Difluoromethylornithine, a Decarboxylase 1 Inhibitor, Suppresses Hepatitis B Virus Replication by Reducing HBc Protein Levels
por: Mao, Binli, et al.
Publicado: (2020)

Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer
por: Hwang, Woo Yeon, et al.
Publicado: (2021)

A pilot study of genomic‐guided induction therapy followed by immunotherapy with difluoromethylornithine maintenance for high‐risk neuroblastoma
por: Kraveka, Jacqueline M., et al.
Publicado: (2022)

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047
por: Murray-Stewart, Tracy, et al.
Publicado: (2017)

Correction: Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047
por: Murray-Stewart, Tracy, et al.
Publicado: (2017)

Synergistic Re-Activation of Epigenetically Silenced Genes by Combinatorial Inhibition of DNMTs and LSD1 in Cancer Cells
por: Han, Han, et al.
Publicado: (2013)

Aberrant Promoter Methylation of the Tumour Suppressor RASSF10 and Its Growth Inhibitory Function in Breast Cancer
por: Richter, Antje M., et al.
Publicado: (2016)

Suppressors of Meiotic Silencing by Unpaired DNA
por: Xiao, Hua, et al.
Publicado: (2019)

RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer
por: Endoh, M, et al.
Publicado: (2005)

Role of dietary polyamines in a phase III clinical trial of difluoromethylornithine (DFMO) and sulindac for prevention of sporadic colorectal adenomas
por: Raj, K P, et al.
Publicado: (2013)

Combined Use of α‐Difluoromethylornithine and an Inhibitor of S‐Adenosylmethionine Decarboxylase in Mice Bearing P388 Leukemia or Lewis Lung Carcinoma
por: Nakaike, Shiro, et al.
Publicado: (1988)

Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer
por: Yeh, Chung-Min, et al.
Publicado: (2016)

NRG1 is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene
por: Chua, Y-L, et al.
Publicado: (2008)

Bacterial pathogens encode suppressors of RNA-mediated silencing
por: Mosher, Rebecca A, et al.
Publicado: (2008)

Screening and Identification of Virus-Encoded RNA Silencing Suppressors
por: Karjee, Sumona, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_4f8t4oucpf0mk7g7qp35eiv5u6