Characterizing low affinity epibatidine binding to α4β2 nicotinic acetylcholine receptors with ligand depletion and nonspecific binding

BACKGROUND: Along with high affinity binding of epibatidine (K(d1)≈10 pM) to α4β2 nicotinic acetylcholine receptor (nAChR), low affinity binding of epibatidine (K(d2)≈1-10 nM) to an independent binding site has been reported. Studying this low affinity binding is important because it might contribut...

Descripción completa

Detalles Bibliográficos
Autores principales: Person, Alexandra M, Wells, Gregg B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287110/
https://www.ncbi.nlm.nih.gov/pubmed/22112852
http://dx.doi.org/10.1186/2046-1682-4-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287110/
https://www.ncbi.nlm.nih.gov/pubmed/22112852
http://dx.doi.org/10.1186/2046-1682-4-19

Ejemplares similares