Cargando…
Characterizing low affinity epibatidine binding to α4β2 nicotinic acetylcholine receptors with ligand depletion and nonspecific binding
BACKGROUND: Along with high affinity binding of epibatidine (K(d1)≈10 pM) to α4β2 nicotinic acetylcholine receptor (nAChR), low affinity binding of epibatidine (K(d2)≈1-10 nM) to an independent binding site has been reported. Studying this low affinity binding is important because it might contribut...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287110/ https://www.ncbi.nlm.nih.gov/pubmed/22112852 http://dx.doi.org/10.1186/2046-1682-4-19 |