RecA homology search is promoted by mechanical stress along the scanned duplex DNA

A RecA–single-stranded DNA (RecA–ssDNA) filament searches a genome for sequence homology by rapidly binding and unbinding double-stranded DNA (dsDNA) until homology is found. We demonstrate that pulling on the opposite termini (3′ and 5′) of one of the two DNA strands in a dsDNA molecule stabilizes...

Descripción completa

Detalles Bibliográficos
Autores principales: Danilowicz, Claudia, Feinstein, Efraim, Conover, Alyson, Coljee, Vincent W., Vlassakis, Julea, Chan, Yuen-Ling, Bishop, Douglas K., Prentiss, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287184/
https://www.ncbi.nlm.nih.gov/pubmed/22013164
http://dx.doi.org/10.1093/nar/gkr855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287184/
https://www.ncbi.nlm.nih.gov/pubmed/22013164
http://dx.doi.org/10.1093/nar/gkr855

Ejemplares similares