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RecA homology search is promoted by mechanical stress along the scanned duplex DNA

A RecA–single-stranded DNA (RecA–ssDNA) filament searches a genome for sequence homology by rapidly binding and unbinding double-stranded DNA (dsDNA) until homology is found. We demonstrate that pulling on the opposite termini (3′ and 5′) of one of the two DNA strands in a dsDNA molecule stabilizes...

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Detalles Bibliográficos
Autores principales:	Danilowicz, Claudia, Feinstein, Efraim, Conover, Alyson, Coljee, Vincent W., Vlassakis, Julea, Chan, Yuen-Ling, Bishop, Douglas K., Prentiss, Mara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287184/ https://www.ncbi.nlm.nih.gov/pubmed/22013164 http://dx.doi.org/10.1093/nar/gkr855

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