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Establishing broad generality of DNA catalysts for site-specific hydrolysis of single-stranded DNA
We recently reported that a DNA catalyst (deoxyribozyme) can site-specifically hydrolyze DNA on the minutes time scale. Sequence specificity is provided by Watson-Crick base pairing between the DNA substrate and two oligonucleotide binding arms that flank the 40-nt catalytic region of the deoxyriboz...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287185/ https://www.ncbi.nlm.nih.gov/pubmed/22021383 http://dx.doi.org/10.1093/nar/gkr860 |