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Establishing broad generality of DNA catalysts for site-specific hydrolysis of single-stranded DNA

We recently reported that a DNA catalyst (deoxyribozyme) can site-specifically hydrolyze DNA on the minutes time scale. Sequence specificity is provided by Watson-Crick base pairing between the DNA substrate and two oligonucleotide binding arms that flank the 40-nt catalytic region of the deoxyriboz...

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Detalles Bibliográficos
Autores principales:	Xiao, Ying, Wehrmann, Rebecca J., Ibrahim, Nora A., Silverman, Scott K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287185/ https://www.ncbi.nlm.nih.gov/pubmed/22021383 http://dx.doi.org/10.1093/nar/gkr860

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