Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability

Microsatellite DNA synthesis represents a significant component of human genome replication that must occur faithfully. However, yeast replicative DNA polymerases do not possess high fidelity for microsatellite synthesis. We hypothesized that the structural features of Y-family polymerases that faci...

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Detalles Bibliográficos
Autores principales: Hile, Suzanne E., Wang, Xiaoxiao, Lee, Marietta Y. W. T., Eckert, Kristin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287198/
https://www.ncbi.nlm.nih.gov/pubmed/22021378
http://dx.doi.org/10.1093/nar/gkr889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287198/
https://www.ncbi.nlm.nih.gov/pubmed/22021378
http://dx.doi.org/10.1093/nar/gkr889

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