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A human XRCC4–XLF complex bridges DNA
DNA double-strand breaks pose a significant threat to cell survival and must be repaired. In higher eukaryotes, such damage is repaired efficiently by non-homologous end joining (NHEJ). Within this pathway, XRCC4 and XLF fulfill key roles required for end joining. Using DNA-binding and -bridging ass...
Autores principales: | Andres, Sara N., Vergnes, Alexandra, Ristic, Dejan, Wyman, Claire, Modesti, Mauro, Junop, Murray |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287209/ https://www.ncbi.nlm.nih.gov/pubmed/22287571 http://dx.doi.org/10.1093/nar/gks022 |
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