Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors

BACKGROUND: Renin has become an attractive target in controlling hypertension because of the high specificity towards its only substrate, angiotensinogen. The conversion of angiotensinogen to angiotensin I is the first and rate-limiting step of renin-angiotensin system and thus designing inhibitors...

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Detalles Bibliográficos
Autores principales: John, Shalini, Thangapandian, Sundarapandian, Arooj, Mahreen, Hong, Jong Chan, Kim, Kwang Dong, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287469/
https://www.ncbi.nlm.nih.gov/pubmed/22372967
http://dx.doi.org/10.1186/1471-2105-12-S14-S4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287469/
https://www.ncbi.nlm.nih.gov/pubmed/22372967
http://dx.doi.org/10.1186/1471-2105-12-S14-S4

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