Cargando…

A methodology for multivariate phenotype-based genome-wide association studies to mine pleiotropic genes

BACKGROUND: Current Genome-Wide Association Studies (GWAS) are performed in a single trait framework without considering genetic correlations between important disease traits. Hence, the GWAS have limitations in discovering genetic risk factors affecting pleiotropic effects. RESULTS: This work repor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Sung Hee, Lee, Ji Young, Kim, Sangsoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287479/ https://www.ncbi.nlm.nih.gov/pubmed/22784570 http://dx.doi.org/10.1186/1752-0509-5-S2-S13

Ejemplares similares

Identifying Pleiotropic Genes in Genome-Wide Association Studies for Multivariate Phenotypes with Mixed Measurement Scales
por: Yang, James J., et al.
Publicado: (2017)

Phenotype prediction from genome-wide association studies: application to smoking behaviors
por: Yoon, Dankyu, et al.
Publicado: (2012)

Penalized multivariate linear mixed model for longitudinal genome-wide association studies
por: Liu, Jin, et al.
Publicado: (2014)

Constrained multivariate association with longitudinal phenotypes
por: Melton, Phillip E., et al.
Publicado: (2016)

Integrating binary traits with quantitative phenotypes for association mapping of multivariate phenotypes
por: Mukhopadhyay, Indranil, et al.
Publicado: (2011)

Shrunken methodology to genome-wide SNPs selection and construction of SNPs networks
por: Liu, Yang, et al.
Publicado: (2010)

A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines
por: Zhu, Wensheng, et al.
Publicado: (2009)

Phenotypic, genetic, and genome-wide structure in the metabolic syndrome
por: Martin, Lisa J, et al.
Publicado: (2003)

Genome-wide association study for multiple phenotype analysis
por: Deng, Xuan, et al.
Publicado: (2018)

Multivariate linkage analysis using the electrophysiological phenotypes in the COGA alcoholism data
por: Zhang, Heping, et al.
Publicado: (2005)

Genome-wide joint analysis of single-nucleotide variant sets and gene expression for hypertension and related phenotypes
por: Tong, Xiaoran, et al.
Publicado: (2016)

Modeling of multivariate longitudinal phenotypes in family genetic studies with Bayesian multiplicity adjustment
por: Ding, Lili, et al.
Publicado: (2014)

Genetic analyses of longitudinal phenotype data: a comparison of univariate methods and a multivariate approach
por: Yang, Qiong, et al.
Publicado: (2003)

Multivariate sib-pair linkage analysis of longitudinal phenotypes by three step-wise analysis approaches
por: Guo, Zheng, et al.
Publicado: (2003)

Genome-wide gene-based association study
por: Yang, Hsin-Chou, et al.
Publicado: (2009)

Treating phenotype as given: a simple resampling method for genome-wide association studies
por: Wang, Kai, et al.
Publicado: (2011)

Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association
por: Rosenberger, Albert, et al.
Publicado: (2005)

A novel transmission-based test of association for multivariate phenotypes: an application to systolic and diastolic blood pressure levels
por: Haldar, Tanushree, et al.
Publicado: (2014)

Localization of genes involved in the metabolic syndrome using multivariate linkage analysis
por: Olswold, Curtis, et al.
Publicado: (2003)

Using text mining techniques to extract phenotypic information from the PhenoCHF corpus
por: Alnazzawi, Noha, et al.
Publicado: (2015)

Genome-wide linkage analysis of systolic blood pressure: a comparison of two approaches to phenotype definition
por: Slager, Susan L, et al.
Publicado: (2003)

Genome-wide association study for empirically derived metabolic phenotypes in the Framingham Heart Study offspring cohort
por: Wilcox, Marsha, et al.
Publicado: (2009)

Region-based analysis in genome-wide association study of Framingham Heart Study blood lipid phenotypes
por: Asimit, Jennifer L, et al.
Publicado: (2009)

Conceptualization of molecular findings by mining gene annotations
por: Chen, Vicky, et al.
Publicado: (2013)

Genome-wide sparse canonical correlation of gene expression with genotypes
por: Parkhomenko, Elena, et al.
Publicado: (2007)

Gene-based bin analysis of genome-wide association studies
por: Omont, Nicolas, et al.
Publicado: (2008)

A novel method to identify high order gene-gene interactions in genome-wide association studies: Gene-based MDR
por: Oh, Sohee, et al.
Publicado: (2012)

Genome-wide linkage and association mapping of disease genes with the GAW14 simulated datasets
por: Carter, Kim W, et al.
Publicado: (2005)

Multivariate hierarchical Bayesian model for differential gene expression analysis in microarray experiments
por: Zhao, Hongya, et al.
Publicado: (2008)

Genome-wide single-nucleotide polymorphism linkage analyses of quantitative rheumatoid arthritis phenotypes in Caucasian NARAC families
por: Taylor, Kimberly E, et al.
Publicado: (2007)

Incorporating biological knowledge in the search for gene × gene interaction in genome-wide association studies
por: Manning, Alisa K, et al.
Publicado: (2009)

Extracting regulatory modules from gene expression data by sequential pattern mining
por: Kim, Mingoo, et al.
Publicado: (2011)

Elastic-net regularization approaches for genome-wide association studies of rheumatoid arthritis
por: Cho, Seoae, et al.
Publicado: (2009)

Linkage mapping of a complex trait in the New York population of the GAW14 simulated dataset: a multivariate phenotype approach
por: Ghosh, Saurabh, et al.
Publicado: (2005)

Joint analysis of multiple blood pressure phenotypes in GAW19 data by using a multivariate rare-variant association test
por: Sun, Jianping, et al.
Publicado: (2016)

Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects
por: Ulgen, Ayse, et al.
Publicado: (2003)

Data for GAW20: genome-wide DNA sequence variation and epigenome-wide DNA methylation before and after fenofibrate treatment in a family study of metabolic phenotypes
por: Aslibekyan, Stella, et al.
Publicado: (2018)

Genome-wide scan on plasma triglyceride and high density lipoprotein cholesterol levels, accounting for the effects of correlated quantitative phenotypes
por: Lin, Jing-Ping
Publicado: (2003)

Network-guided interaction mining for the blood pressure phenotype of unrelated individuals in genetic analysis workshop 19
por: Lo, Adeline, et al.
Publicado: (2016)

A genome-wide linkage study of GAW15 gene expression data
por: Kan, Donghui, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_qhsa7rg0ja7gvf8hlbskq76k38