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Changes in predicted protein disorder tendency may contribute to disease risk

BACKGROUND: Recent studies suggest that many proteins or regions of proteins lack 3D structure. Defined as intrinsically disordered proteins, these proteins/peptides are functionally important. Recent advances in next generation sequencing technologies enable genome-wide identification of novel nucl...

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Detalles Bibliográficos
Autores principales: Hu, Yang, Liu, Yunlong, Jung, Jeesun, Dunker, A Keith, Wang, Yadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287498/
https://www.ncbi.nlm.nih.gov/pubmed/22369681
http://dx.doi.org/10.1186/1471-2164-12-S5-S2