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Improved power by collapsing rare and common variants based on a data-adaptive forward selection strategy
Genome-wide association studies have been used successfully to detect associations between common genetic variants and complex diseases, but common single-nucleotide polymorphisms (SNPs) detected by these studies explain only 5–10% of disease heritability. Alternatively, the common disease/rare vari...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287838/ https://www.ncbi.nlm.nih.gov/pubmed/22373230 http://dx.doi.org/10.1186/1753-6561-5-S9-S114 |