Cargando…

Identifying rare disease variants in the Genetic Analysis Workshop 17 simulated data: a comparison of several statistical approaches

Genome-wide association studies have been successful at identifying common disease variants associated with complex diseases, but the common variants identified have small effect sizes and account for only a small fraction of the estimated heritability for common diseases. Theoretical and empirical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Ruixue, Huang, Chien-Hsun, Lo, Shaw-Hwa, Zheng, Tian, Ionita-Laza, Iuliana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287851/ https://www.ncbi.nlm.nih.gov/pubmed/22373071 http://dx.doi.org/10.1186/1753-6561-5-S9-S17

Ejemplares similares

New insights into old methods for identifying causal rare variants
por: Wang, Haitian, et al.
Publicado: (2011)

Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm
por: Ding, Yuejing, et al.
Publicado: (2007)

Joint study of genetic regulators for expression traits related to breast cancer
por: Zheng, Tian, et al.
Publicado: (2007)

Identifying influential regions in extremely rare variants using a fixed-bin approach
por: Agne, Michael, et al.
Publicado: (2011)

Small sample properties of rare variant analysis methods
por: Swartz, Michael D, et al.
Publicado: (2014)

A partition-based approach to identify gene-environment interactions in genome wide association studies
por: Fan, Ruixue, et al.
Publicado: (2014)

Association screening for genes with multiple potentially rare variants: an inverse-probability weighted clustering approach
por: Liu, Ying, et al.
Publicado: (2011)

Comparing the power of family-based association tests for sequence data with applications in the GAW18 simulated data
por: Huang, Jing, et al.
Publicado: (2014)

Considering interactive effects in the identification of influential regions with extremely rare variants via fixed bin approach
por: Agne, Michael, et al.
Publicado: (2014)

Evaluation of association tests for rare variants using simulated data sets in the Genetic Analysis Workshop 17 data
por: Chen, Wenan, et al.
Publicado: (2011)

Identifying causal rare variants of disease through family-based analysis of Genetics Analysis Workshop 17 data set
por: Yip, Wai-Ki, et al.
Publicado: (2011)

Discovering pure gene-environment interactions in blood pressure genome-wide association studies data: a two-step approach incorporating new statistics
por: Wang, Maggie Haitian, et al.
Publicado: (2014)

Integrative analysis of functional genomic annotations and sequencing data to identify rare causal variants via hierarchical modeling
por: Capanu, Marinela, et al.
Publicado: (2015)

Identifying rare variants from exome scans: the GAW17 experience
por: Ghosh, Saurabh, et al.
Publicado: (2011)

Identifying regions of disease-related variants in admixed populations with the summation partition approach
por: Auerbach, Jonathan, et al.
Publicado: (2016)

Genetic Analysis Workshop 17 mini-exome simulation
por: Almasy, Laura, et al.
Publicado: (2011)

Challenges and directions: an analysis of Genetic Analysis Workshop 17 data by collapsing rare variants within family data
por: Lin, Peng, et al.
Publicado: (2011)

Detecting functional rare variants by collapsing and incorporating functional annotation in Genetic Analysis Workshop 17 mini-exome data
por: Yan, Xiting, et al.
Publicado: (2011)

A New Testing Strategy to Identify Rare Variants with Either Risk or Protective Effect on Disease
por: Ionita-Laza, Iuliana, et al.
Publicado: (2011)

A dual-clustering framework for association screening with whole genome sequencing data and longitudinal traits
por: Liu, Ying, et al.
Publicado: (2014)

Different approaches for dealing with rare variants in family-based genetic studies: application of a Genetic Analysis Workshop 17 problem
por: Alfonso de Almeida, Marcio Augusto, et al.
Publicado: (2011)

Pathway-based joint effects analysis of rare genetic variants using Genetic Analysis Workshop 17 exon sequence data
por: Hu, Pingzhao, et al.
Publicado: (2011)

Rare variant collapsing in conjunction with mean log p-value and gradient boosting approaches applied to Genetic Analysis Workshop 17 data
por: Cherkas, Yauheniya, et al.
Publicado: (2011)

Addition of multiple rare SNPs to known common variants improves the association between disease and gene in the Genetic Analysis Workshop 17 data
por: Sykes, Jenna, et al.
Publicado: (2011)

Network-guided interaction mining for the blood pressure phenotype of unrelated individuals in genetic analysis workshop 19
por: Lo, Adeline, et al.
Publicado: (2016)

Rare Variant Analysis for Family-Based Design
por: De, Gourab, et al.
Publicado: (2013)

Comparison of collapsing methods for the statistical analysis of rare variants
por: Dering, Carmen, et al.
Publicado: (2011)

Rheumatoid arthritis-associated gene-gene interaction network for rheumatoid arthritis candidate genes
por: Huang, Chien-Hsun, et al.
Publicado: (2009)

Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1
por: Qiao, Bo, et al.
Publicado: (2009)

Propensity score analysis in the Genetic Analysis Workshop 17 simulated data set on independent individuals
por: Lin, Chen Min, et al.
Publicado: (2011)

Comparison of statistical approaches to rare variant analysis for quantitative traits
por: Chen, Han, et al.
Publicado: (2011)

Use of Bayesian networks to dissect the complexity of genetic disease: application to the Genetic Analysis Workshop 17 simulated data
por: Kang, Jia, et al.
Publicado: (2011)

Identifying rare and common variants with Bayesian variable selection
por: Oh, Cheongeun
Publicado: (2016)

A novel statistical method for rare-variant association studies in general pedigrees
por: Zhu, Huanhuan, et al.
Publicado: (2016)

Genome-wide case-control study in GAW17 using coalesced rare variants
por: Wang, Libo, et al.
Publicado: (2011)

Identifying rare variants using a Bayesian regression approach
por: Yan, Aimin, et al.
Publicado: (2011)

A clustering approach to identify rare variants associated with hypertension
por: Sun, Rui, et al.
Publicado: (2016)

Comparative study of statistical methods for detecting association with rare variants in exome-resequencing data
por: Saad, Mohamad, et al.
Publicado: (2011)

Confidence set of putative quantitative trait loci in whole genome scans with application to the Genetic Analysis Workshop 17 simulated data
por: Papachristou, Charalampos
Publicado: (2011)

Comparison of multilevel modeling and the family-based association test for identifying genetic variants associated with systolic and diastolic blood pressure using Genetic Analysis Workshop 18 simulated data
por: Wang, Jian, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0iiji5jm3abjtammqidmkhove8