Methods for adjusting population structure and familial relatedness in association test for collective effect of multiple rare variants on quantitative traits

Because of the low frequency of rare genetic variants in observed data, the statistical power of detecting their associations with target traits is usually low. The collapsing test of collective effect of multiple rare variants is an important and useful strategy to increase the power; in addition,...

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Detalles Bibliográficos
Autores principales: Zhang, Qunyuan, Chung, Doyoung, Kraja, Aldi, Borecki, Ingrid I, Province, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287871/
https://www.ncbi.nlm.nih.gov/pubmed/22373066
http://dx.doi.org/10.1186/1753-6561-5-S9-S35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287871/
https://www.ncbi.nlm.nih.gov/pubmed/22373066
http://dx.doi.org/10.1186/1753-6561-5-S9-S35

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