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Methods for adjusting population structure and familial relatedness in association test for collective effect of multiple rare variants on quantitative traits
Because of the low frequency of rare genetic variants in observed data, the statistical power of detecting their associations with target traits is usually low. The collapsing test of collective effect of multiple rare variants is an important and useful strategy to increase the power; in addition,...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287871/ https://www.ncbi.nlm.nih.gov/pubmed/22373066 http://dx.doi.org/10.1186/1753-6561-5-S9-S35 |