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Enrichment analysis of genetic association in genes and pathways by aggregating signals from both rare and common variants

New high-throughput sequencing technologies have brought forth opportunities for unbiased analysis of thousands of rare genomic variants in genome-wide association studies of complex diseases. Because it is hard to detect single rare variants with appreciable effect sizes at the population level, ex...

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Detalles Bibliográficos
Autores principales: Yang, Wei, Gu, C Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287890/
https://www.ncbi.nlm.nih.gov/pubmed/22373052
http://dx.doi.org/10.1186/1753-6561-5-S9-S52