A weighted accumulation test for associating rare genetic variation with quantitative phenotypes

Currently there is a great deal of interest in developing methods for testing the role that rare variation plays in disease development. Here we propose a weighted association test that accumulates genetic variation across a signaling pathway. We evaluate our approach by analyzing simulated phenotyp...

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Detalles Bibliográficos
Autores principales: Xing, Chuanhua, Satten, Glen A, Allen, Andrew S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287898/
https://www.ncbi.nlm.nih.gov/pubmed/22373271
http://dx.doi.org/10.1186/1753-6561-5-S9-S6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287898/
https://www.ncbi.nlm.nih.gov/pubmed/22373271
http://dx.doi.org/10.1186/1753-6561-5-S9-S6

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