Power of association tests in the presence of multiple causal variants

We show that the statistical power of a single single-nucleotide polymorphism (SNP) score test for genetic association reflects the cumulative effect of all causal SNPs that are correlated with the test SNP. Statistical significance of a score test can sometimes be explained by the collective effect...

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Detalles Bibliográficos
Autores principales: Di, Yanming, Mi, Gu, Sun, Luna, Dong, Rongrong, Zhu, Hong, Peng, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287902/
https://www.ncbi.nlm.nih.gov/pubmed/22373395
http://dx.doi.org/10.1186/1753-6561-5-S9-S63

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287902/
https://www.ncbi.nlm.nih.gov/pubmed/22373395
http://dx.doi.org/10.1186/1753-6561-5-S9-S63

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