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Power of association tests in the presence of multiple causal variants

We show that the statistical power of a single single-nucleotide polymorphism (SNP) score test for genetic association reflects the cumulative effect of all causal SNPs that are correlated with the test SNP. Statistical significance of a score test can sometimes be explained by the collective effect...

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Detalles Bibliográficos
Autores principales:	Di, Yanming, Mi, Gu, Sun, Luna, Dong, Rongrong, Zhu, Hong, Peng, Lili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287902/ https://www.ncbi.nlm.nih.gov/pubmed/22373395 http://dx.doi.org/10.1186/1753-6561-5-S9-S63

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