Two-stage study designs combining genome-wide association studies, tag single-nucleotide polymorphisms, and exome sequencing: accuracy of genetic effect estimates

Genome-wide association studies (GWAS) test for disease-trait associations and estimate effect sizes at tag single-nucleotide polymorphisms (SNPs), which imperfectly capture variation at causal SNPs. Sequencing studies can examine potential causal SNPs directly; however, sequencing the whole genome...

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Detalles Bibliográficos
Autores principales: Faye, Laura L, Bull, Shelley B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287903/
https://www.ncbi.nlm.nih.gov/pubmed/22373407
http://dx.doi.org/10.1186/1753-6561-5-S9-S64

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287903/
https://www.ncbi.nlm.nih.gov/pubmed/22373407
http://dx.doi.org/10.1186/1753-6561-5-S9-S64

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