Cargando…

Identifying variants that contribute to linkage for dichotomous and quantitative traits in extended pedigrees

Compared to genome-wide association analysis, linkage analysis is less influenced by allelic heterogeneity. The use of linkage information in large families should provide a great opportunity to identify less frequent variants. We perform a linkage scan for both dichotomous and quantitative traits i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Wei-Min, Manichaikul, Ani, Rich, Stephen S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287907/ https://www.ncbi.nlm.nih.gov/pubmed/22373516 http://dx.doi.org/10.1186/1753-6561-5-S9-S68

Ejemplares similares

Identity by descent and association analysis of dichotomous traits based on large pedigrees
por: Liu, Tian, et al.
Publicado: (2011)

The Cluster Variation Method for Efficient Linkage Analysis on Extended Pedigrees
por: Albers, Cornelis A, et al.
Publicado: (2006)

Linkage analysis of anti-CCP levels as dichotomized and quantitative traits using GAW15 single-nucleotide polymorphism scan of NARAC families
por: Yang, Xiaohong R, et al.
Publicado: (2007)

Comparisons of methods for linkage analysis and haplotype reconstruction using extended pedigree data
por: Lin, Shili, et al.
Publicado: (2005)

Family-based tests applied to extended pedigrees identify rare variants related to hypertension
por: Xu, Mengyuan, et al.
Publicado: (2014)

The effect of linkage disequilibrium on linkage analysis of incomplete pedigrees
por: Levinson, Douglas F, et al.
Publicado: (2005)

Linkage and association analysis in pedigrees from different populations
por: Beyene, Joseph, et al.
Publicado: (2005)

Fast genome-wide pedigree quantitative trait loci analysis using MENDEL
por: Zhou, Hua, et al.
Publicado: (2014)

Using linkage analysis of large pedigrees to guide association analyses
por: Choi, Seung-Hoan, et al.
Publicado: (2011)

The feasibility of oligogenic combined segregation and linkage analysis in CEPH pedigrees
por: Daw, E Warwick, et al.
Publicado: (2007)

Multiphase analysis by linkage, quantitative transmission disequilibrium, and measured genotype: systolic blood pressure in complex Mexican American pedigrees
por: Chen, Zhijian, et al.
Publicado: (2014)

Comparing family-based rare variant association tests for dichotomous phenotypes
por: Wang, Longfei, et al.
Publicado: (2016)

Comparison of linkage analysis methods for genome-wide scanning of extended pedigrees, with application to the TG/HDL-C ratio in the Framingham Heart Study
por: Horne, Benjamin D, et al.
Publicado: (2003)

New score tests for age-at-onset linkage analysis in general pedigrees
por: Callegaro, Andrea, et al.
Publicado: (2009)

Whole genome sequencing data from pedigrees suggests linkage disequilibrium among rare variants created by population admixture
por: Feng, Tao, et al.
Publicado: (2014)

Segregation and linkage analysis for longitudinal measurements of a quantitative trait
por: Gee, Conway, et al.
Publicado: (2003)

Quantitative trait linkage analysis of longitudinal change in body weight
por: Golla, Astrid, et al.
Publicado: (2003)

Methods for detecting gene × gene interaction in multiplex extended pedigrees
por: Brock, Guy N, et al.
Publicado: (2005)

Comparison of linkage and association strategies for quantitative traits using the COGA dataset
por: McQueen, Matthew B, et al.
Publicado: (2005)

Two novel quantitative trait linkage analysis statistics based on the posterior probability of linkage: application to the COGA families
por: Bartlett, Christopher W, et al.
Publicado: (2005)

Effects on linkage analyses of different Affymetrix expression measures as quantitative trait phenotypes
por: Peralta, Juan Manuel, et al.
Publicado: (2007)

Genome-wide linkage scan on estimated breeding values for a quantitative trait
por: Zabaneh, Delilah, et al.
Publicado: (2003)

Normalization of microarray expression data using within-pedigree pool and its effect on linkage analysis
por: Kim, Yoonhee, et al.
Publicado: (2007)

Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
por: Knight, Jo, et al.
Publicado: (2003)

Linkage analysis of the GAW14 simulated dataset with microsatellite and single-nucleotide polymorphism markers in large pedigrees
por: Yang, Xiaohong (Rose), et al.
Publicado: (2005)

Confidence intervals for putative quantitative trait loci – development and applications of new linkage methods
por: Papachristou, Charalampos, et al.
Publicado: (2007)

Quantitative trait locus-specific genotype × alcoholism interaction on linkage for evoked electroencephalogram oscillations
por: Martin, Lisa J, et al.
Publicado: (2005)

Using Extended Genealogy to Estimate Components of Heritability for 23 Quantitative and Dichotomous Traits
por: Zaitlen, Noah, et al.
Publicado: (2013)

A Bayesian genome-wide linkage analysis of quantitative traits for rheumatoid arthritis via perfect sampling
por: Oh, Cheongeun
Publicado: (2007)

The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification
por: Havill, Lorena M, et al.
Publicado: (2005)

An exploration of heterogeneity in genetic analysis of complex pedigrees: linkage and association using whole genome sequencing data in the MAP4 region
por: Bull, Shelley B, et al.
Publicado: (2014)

A novel statistical method for rare-variant association studies in general pedigrees
por: Zhu, Huanhuan, et al.
Publicado: (2016)

Structural equation modeling with latent variables for longitudinal blood pressure traits using general pedigrees
por: Song, Yeunjoo E., et al.
Publicado: (2016)

Single-nucleotide polymorphism versus microsatellite markers in a combined linkage and segregation analysis of a quantitative trait
por: Daw, E Warwick, et al.
Publicado: (2005)

Genome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic
por: Hendricks, Audrey E, et al.
Publicado: (2009)

Two-stage analyses of sequence variants in association with quantitative traits
por: Barrett, Jennifer H, et al.
Publicado: (2011)

Comparison of statistical approaches to rare variant analysis for quantitative traits
por: Chen, Han, et al.
Publicado: (2011)

Pedigree association: assigning individual weights to pedigree members for genetic association analysis
por: Knight, Stacey, et al.
Publicado: (2009)

Quantitative trait locus linkage analysis in a large Amish pedigree identifies novel candidate loci for erythrocyte traits
por: Hinckley, Jesse D, et al.
Publicado: (2013)

Identifying cryptic population structure in multigenerational pedigrees in a Mexican American sample
por: Culverhouse, Robert C, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_oolk1utfr3dc6q446tgst3mtlh