Identity-by-descent filtering as a tool for the identification of disease alleles in exome sequence data from distant relatives

Large-scale, deep resequencing may be the next logical step in the genetic investigation of common complex diseases. Because each individual is likely to carry many thousands of variants, the identification of causal alleles requires an efficient strategy to reduce the number of candidate variants....

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Detalles Bibliográficos
Autores principales: Akula, Nirmala, Detera-Wadleigh, Sevilla, Shugart, Yin Yao, Nalls, Michael, Steele, Jo, McMahon, Francis J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287916/
https://www.ncbi.nlm.nih.gov/pubmed/22373213
http://dx.doi.org/10.1186/1753-6561-5-S9-S76

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287916/
https://www.ncbi.nlm.nih.gov/pubmed/22373213
http://dx.doi.org/10.1186/1753-6561-5-S9-S76

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