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Capability of common SNPs to tag rare variants

Genome-wide association studies are based on the linkage disequilibrium pattern between common tagging single-nucleotide polymorphisms (SNPs) (i.e., SNPs having only common alleles) and true causal variants, and association studies with rare SNP alleles aim to detect rare causal variants. To better...

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Detalles Bibliográficos
Autores principales: Sun, Xiangqing, Namkung, Junghyun, Zhu, Xiaofeng, Elston, Robert C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287929/
https://www.ncbi.nlm.nih.gov/pubmed/22373521
http://dx.doi.org/10.1186/1753-6561-5-S9-S88