Investigating the Structural Impacts of I64T and P311S Mutations in APE1-DNA Complex: A Molecular Dynamics Approach

BACKGROUND: Elucidating the molecular dynamic behavior of Protein-DNA complex upon mutation is crucial in current genomics. Molecular dynamics approach reveals the changes on incorporation of variants that dictate the structure and function of Protein-DNA complexes. Deleterious mutations in APE1 pro...

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Detalles Bibliográficos
Autores principales: Doss, C. George Priya, NagaSundaram, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288039/
https://www.ncbi.nlm.nih.gov/pubmed/22384055
http://dx.doi.org/10.1371/journal.pone.0031677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288039/
https://www.ncbi.nlm.nih.gov/pubmed/22384055
http://dx.doi.org/10.1371/journal.pone.0031677

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