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Mechanism-Based Screen Establishes Signalling Framework for DNA Damage-Associated G1 Checkpoint Response

DNA damage activates checkpoint controls which block progression of cells through the division cycle. Several different checkpoints exist that control transit at different positions in the cell cycle. A role for checkpoint activation in providing resistance of cells to genotoxic anticancer therapy,...

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Detalles Bibliográficos
Autores principales: Richardson, Elizabeth, Stockwell, Simon R., Li, He, Aherne, Wynne, Cuomo, Maria Emanuela, Mittnacht, Sibylle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288045/
https://www.ncbi.nlm.nih.gov/pubmed/22384045
http://dx.doi.org/10.1371/journal.pone.0031627