Aptamers as a Sensitive Tool to Detect Subtle Modifications in Therapeutic Proteins

Therapeutic proteins are derived from complex expression/production systems, which can result in minor conformational changes due to preferential codon usage in different organisms, post-translational modifications, etc. Subtle conformational differences are often undetectable by bioanalytical metho...

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Detalles Bibliográficos
Autores principales: Zichel, Ran, Chearwae, Wanida, Pandey, Gouri Shankar, Golding, Basil, Sauna, Zuben E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288073/
https://www.ncbi.nlm.nih.gov/pubmed/22384109
http://dx.doi.org/10.1371/journal.pone.0031948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288073/
https://www.ncbi.nlm.nih.gov/pubmed/22384109
http://dx.doi.org/10.1371/journal.pone.0031948

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