Transforming and Tumorigenic Activity of JAK2 by Fusion to BCR: Molecular Mechanisms of Action of a Novel BCR-JAK2 Tyrosine-Kinase

Chromosomal translocations in tumors frequently produce fusion genes coding for chimeric proteins with a key role in oncogenesis. Recent reports described a BCR-JAK2 fusion gene in fatal chronic and acute myeloid leukemia, but the functional behavior of the chimeric protein remains uncharacterized....

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Detalles Bibliográficos
Autores principales: Cuesta-Domínguez, Álvaro, Ortega, Mara, Ormazábal, Cristina, Santos-Roncero, Matilde, Galán-Díez, Marta, Steegmann, Juan Luis, Figuera, Ángela, Arranz, Eva, Vizmanos, José Luis, Bueren, Juan A., Río, Paula, Fernández-Ruiz, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288102/
https://www.ncbi.nlm.nih.gov/pubmed/22384256
http://dx.doi.org/10.1371/journal.pone.0032451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288102/
https://www.ncbi.nlm.nih.gov/pubmed/22384256
http://dx.doi.org/10.1371/journal.pone.0032451

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