Elevated and sustained Egr1 and Egr2 expression controls NKT lineage differentiation in response to TCR signaling

TCR-driven interactions determine the lineage choice of CD4(+)CD8(+) thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we show that TCR-induced Egr2 and Egr1 proteins had elevated and prolonged expression in NKT lineage precursors co...

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Detalles Bibliográficos
Autores principales: Seiler, Michael P., Mathew, Rebecca, Liszewski, Megan K., Spooner, Chauncey, Barr, Kenneth, Meng, Fanyong, Singh, Harinder, Bendelac, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288314/
https://www.ncbi.nlm.nih.gov/pubmed/22306690
http://dx.doi.org/10.1038/ni.2230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288314/
https://www.ncbi.nlm.nih.gov/pubmed/22306690
http://dx.doi.org/10.1038/ni.2230

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