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Elevated and sustained Egr1 and Egr2 expression controls NKT lineage differentiation in response to TCR signaling
TCR-driven interactions determine the lineage choice of CD4(+)CD8(+) thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we show that TCR-induced Egr2 and Egr1 proteins had elevated and prolonged expression in NKT lineage precursors co...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288314/ https://www.ncbi.nlm.nih.gov/pubmed/22306690 http://dx.doi.org/10.1038/ni.2230 |