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A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction

NMDA receptors (NMDARs) are glutamate-gated ion channels present at most excitatory mammalian synapses. The four GluN2 subunits (GluN2A–D) contribute to four diheteromeric NMDAR subtypes that play divergent physiological and pathological roles. Channel properties fundamental to NMDAR function vary a...

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Detalles Bibliográficos
Autores principales: Retchless, Beth Siegler, Gao, Wei, Johnson, Jon W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288527/
https://www.ncbi.nlm.nih.gov/pubmed/22246434
http://dx.doi.org/10.1038/nn.3025