Evidence for dynamics in proteins as a mechanism for ligand dissociation

Signal transduction, regulatory processes, and pharmaceutical responses are highly dependent upon ligand residence times. Gaining insight into how physical factors influence residence times, or k(off), should enhance our ability to manipulate biological interactions. We report experiments that yield...

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Detalles Bibliográficos
Autores principales: Carroll, Mary J., Mauldin, Randall V., Gromova, Anna V., Singleton, Scott F., Collins, Edward J., Lee, Andrew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288659/
https://www.ncbi.nlm.nih.gov/pubmed/22246400
http://dx.doi.org/10.1038/nchembio.769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288659/
https://www.ncbi.nlm.nih.gov/pubmed/22246400
http://dx.doi.org/10.1038/nchembio.769

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