Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis

Adult-onset diseases can be associated with in utero events, but mechanisms for this remain unknown(1,2). The polycomb histone methyltransferase, Ezh2, stabilizes transcription by depositing repressive marks during development that persist into adulthood(3–9), but its function in postnatal organ hom...

Descripción completa

Detalles Bibliográficos
Autores principales: Delgado-Olguín, Paul, Huang, Yu, Li, Xue, Christodoulou, Danos, Seidman, Christine E., Seidman, J.G., Tarakhovsky, Alexander, Bruneau, Benoit G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288669/
https://www.ncbi.nlm.nih.gov/pubmed/22267199
http://dx.doi.org/10.1038/ng.1068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288669/
https://www.ncbi.nlm.nih.gov/pubmed/22267199
http://dx.doi.org/10.1038/ng.1068

Ejemplares similares