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Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
Adult-onset diseases can be associated with in utero events, but mechanisms for this remain unknown(1,2). The polycomb histone methyltransferase, Ezh2, stabilizes transcription by depositing repressive marks during development that persist into adulthood(3–9), but its function in postnatal organ hom...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288669/ https://www.ncbi.nlm.nih.gov/pubmed/22267199 http://dx.doi.org/10.1038/ng.1068 |